Carmichael, Polly and Butler, Gary and Masic, Una and Cole, Tim and De Stavola, Bianca and Davidson, Sarah and Skageberg, Elin and Khadr, Sophie and Viner, Russell M
(2021).
Short-term outcomes of pubertal suppression in a selected cohort of 12 to 15 year old young people with persistent gender dysphoria in the UK 2019-2021.
[Data Collection]. Colchester, Essex:
UK Data Service.
10.5255/UKDA-SN-854413
Data description (abstract)
In adolescents with severe and persistent gender dysphoria (GD), gonadotropin releasing hormone analogues (GnRHa) are used from early/middle puberty with the aim of delaying irreversible and unwanted pubertal body changes. Evidence of outcomes of pubertal suppression in GD is limited. We undertook an uncontrolled prospective observational study of GnRHa as monotherapy in 44 12-15 year olds with persistent and severe GD. Prespecified analyses were limited to key outcomes: bone mineral content (BMC) and bone mineral density (BMD); Child Behaviour CheckList (CBCL) total t-score; Youth Self-Report (YSR) total t-score; CBCL and YSR self-harm indices; at 12, 24 and 36 months. Semi-structured interviews were conducted on GnRHa.
| Data creators: |
| Creator Name |
Affiliation |
ORCID (as URL) |
| Carmichael Polly |
Tavistock and Portman NHS Foundation Trust |
|
| Butler Gary |
Tavistock and Portman NHS Foundation Trust |
|
| Masic Una |
Tavistock and Portman NHS Foundation Trust |
|
| Cole Tim |
University College London |
|
| De Stavola Bianca |
University College London |
|
| Davidson Sarah |
Tavistock and Portman NHS Foundation Trust |
|
| Skageberg Elin |
Tavistock and Portman NHS Foundation Trust |
|
| Khadr Sophie |
University College London |
|
| Viner Russell M |
UCL Great Ormond St. Institute of Child Health |
https://orcid.org/0000-0003-3047-2247
|
|
| Sponsors: |
N/A
|
| Topic classification: |
Health
Society and culture
Psychology
|
| Keywords: |
GENDER ROLE, ADOLESCENT PSYCHOLOGY, TRANSGENDER, PUBERTY, CHILD BEHAVIOUR, SELF HARM, YOUTH, SOCIOLOGY OF THE BODY, BEHAVIOUR, LIFESTYLE AND BEHAVIOUR
|
| Project dates: |
| From | To |
|---|
| 1 April 2011 | 30 April 2019 |
|
| Date published: |
08 Jan 2021 10:48
|
| Last modified: |
15 Jan 2021 11:44
|
| Collection period: |
| Date from: | Date to: |
|---|
| 1 April 2011 | 28 February 2019 |
|
| Geographical area: |
London |
| Country: |
United Kingdom |
| Data collection method: |
We undertook an uncontrolled prospective observational study of GnRHa as monotherapy in 44 12-15 year olds with persistent and severe GD. Prespecified analyses were limited to key outcomes: bone mineral content (BMC) and bone mineral density (BMD); Child Behaviour CheckList (CBCL) total t-score; Youth Self-Report (YSR) total t-score; CBCL and YSR self-harm indices; at 12, 24 and 36 months. Semi-structured interviews were conducted on GnRHa. During the recruitment period (April 2011- April 2014), there were 137 young people who were potentially eligible for the study; i.e. aged between 11 and 14.15 years and in the Tavistock service for over 6 months. Of these, 48 young people (35%) requested to be attend the UCLH clinics for information about and assessment for the study. 4 did not seek further involvement after the first appointment, leaving 44 young people taking part in the study. |
| Observation unit: |
Individual |
| Kind of data: |
Numeric, Text |
| Type of data: |
Cohort and longitudinal studies, Other surveys |
| Resource language: |
English |
|
| Data sourcing, processing and preparation: |
Data deposited here have been carefully anonymised, with removal of sensitive data that may allow re-identification when combined with publicly available data. Outcome data are deposited only as standardized data i.e. data standardised for age and sex to avoid potential re-identification. Data have been deposited in the interests of transparency and open science, to enable analyses to be replicated, with the agreement of the Health Research Authority (HRA), UK.
|
| Rights owners: |
| Name |
Affiliation |
ORCID (as URL) |
| Carmichael Polly |
Tavistock and Portman NHS Foundation Trust |
|
|
| Contact: |
| Name | Email | Affiliation | ORCID (as URL) |
|---|
| Carmichael, Polly | pcarmichael@tavi-port.nhs.uk | Tavistock and Portman NHS Foundation Trust | Unspecified |
|
| Notes on access: |
The Data Collection is available to any user without the requirement for registration for download/access.
|
| Publisher: |
UK Data Service
|
| Last modified: |
15 Jan 2021 11:44
|
|
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