H.Al Wattar, Bassel and Fisher, Maria and Bevington, Laura and Talaulikar, Vikram and Davies, Melanie and Conway, Gerrad and Yasmin, Ephia
(2021).
Clinical Practice Guidelines on the Diagnosis and Management of Polycystic Ovary Syndrome: A Systematic Review and Quality Assessment Study, 2007-2018.
[Data Collection]. Colchester, Essex:
UK Data Service.
10.5255/UKDA-SN-854760
Data description (abstract)
Clinical practice guidelines (CPGs) are key instruments to implement the practice of evidence-based medicine. We aimed to evaluate the methodological quality and variations in CPGs recommendations on the diagnosis and management of polycystic ovary syndrome (PCOS). We searched MEDLINE, EMBASE, and CENTRAL until December 2020 for all evidence-based CPGs and consensus statements on PCOS. We extracted data in duplicate to map clinical recommendations across pre-specified disease domains and assessed CPGs methodological quality of using the AGREE II tool. We included thirteen PCOS CPGs were published between 2007-2018. CPGs recommendations were mostly focused on screening for and managing metabolic disease (12/13, 92%), followed by cardiovascular risk assessment (10/13, 77%). Mental health (8/13, 62%) and diagnosis in adolescents (7/13, 54%) were the least reported domains. Most CPGs had a high quality for scope and purpose description (12/13, 92%) while stakeholder’s involvement and applicability of recommendations to clinical practice were appropriate in only two CPGs (2/13, 15%).
We identified inconsistency in recommendations on PCOS diagnosis in adolescents, optimal lifestyle interventions, hirsutism and acne treatments, interventions to reduce the risk of ovarian hyperstimulation syndrome, the frequency and screening criteria for metabolic and cardiovascular disease, and on optimal screening tools for mental health illness in women with PCOS. Current CPGs on the diagnosis and management of PCOS vary in their scope and methodological quality which may hinder evidence translation into clinical practice. We identified disease domains with existing evidence gap to guide future research and guideline updates.
| Data creators: |
| Creator Name |
Affiliation |
ORCID (as URL) |
| H.Al Wattar Bassel |
University of Warwick |
https://orcid.org/0000-0001-8287-9271
|
| Fisher Maria |
University Hospital Coventry & Warwickshire |
|
| Bevington Laura |
University Hospital Coventry & Warwickshire |
|
| Talaulikar Vikram |
University College London Hospitals |
|
| Davies Melanie |
University College London Hospitals |
|
| Conway Gerrad |
University College London Hospitals |
|
| Yasmin Ephia |
University College London Hospitals |
|
|
| Sponsors: |
NIHR
|
| Topic classification: |
Health
|
| Keywords: |
QUALITY, Polycystic ovary syndrome, clinical guideline, systematic review, evidence synthesis
|
| Project title: |
Clinical practice guidelines on the diagnosis and management of polycystic ovary syndrome: A systematic review and quality assessment study
|
| Grant holders: |
Bassel H.Al Wattar
|
| Date published: |
14 Apr 2021 09:47
|
| Last modified: |
14 Apr 2021 09:48
|
| Collection period: |
| Date from: | Date to: |
|---|
| 1 January 2007 | 31 December 2018 |
|
| Country: |
United Kingdom |
| Data collection method: |
We searched MEDLINE, EMBASE, and Cochrane CENTRAL databases within the NICE Healthcare Database Advanced Search platform (hdas.nice.org.uk) using the following search terms to identify eligible CPGs on PCOS from inception until December 2020: Clinical, CPGs, consensus statement, position statement, recommendation?, polycystic ovary, polycystic ovary syndrome, hyperandrogen*, anovulation, *menorrhea, wom?n, female, pregnan*. Complementary searches were conducted in Google Scholar, Tripdatabase and Scopus. We searched the websites of established regulatory bodies on the topic of care for women with PCOS to identify relevant CPGs. We did not apply any search filters or language limitations.
Two independent reviewers (LB and MF) extracted data in duplicate into an electronic Excel sheet which was piloted for its face validity. Data integrity was double-checked by a third reviewer (BHA). We extracted data on the following guideline characteristics: producing authority, named authors, country of origin, year of publication, consensus method, stakeholders involved, disease domain addressed in the CPG, description of the search strategy to identify evidence, inclusion/exclusion criteria of evidence, quality assessment instruments used, grading system used. We mapped out the clinical recommendations in each guideline and tabulated them into the following pre-specified domains: diagnosis in adolescents and adults; lifestyle interventions; management of menstrual irregularity, hirsutism, acne, and infertility; risk assessment for metabolic disease, cardiovascular disease, mental health, and cancer. |
| Observation unit: |
Other |
| Kind of data: |
Text |
| Type of data: |
Cohort and longitudinal studies |
| Resource language: |
English |
|
| Data sourcing, processing and preparation: |
We calculated a total quality score for each guideline by adding the scores of the evaluated quality domains and standardising them using a prescribed equation10. We reported on descriptive data using normal frequencies, median and ranges. We assessed correlation coefficients using Pearson correlation test. All statistical analyses were conducted using Microsoft Excel (Excel 2017, Microsoft, Redmond, Washington).
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| Rights owners: |
| Name |
Affiliation |
ORCID (as URL) |
| H.Al Wattar Bassel |
|
|
|
| Contact: |
| Name | Email | Affiliation | ORCID (as URL) |
|---|
| H.Al Wattar, Bassel | b.wattar@nhs.net | Unspecified | Unspecified |
|
| Notes on access: |
The Data Collection is available to any user without the requirement for registration for download/access.
|
| Publisher: |
UK Data Service
|
| Last modified: |
14 Apr 2021 09:48
|
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